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Office: 308D Briggs Hall
Phone: (530) 752-7755
Email: wsleal@ucdavis.edu
Fax:
(530) 754-8682
complete CV (PDF) |
Walter S. Leal,
Ph.D.
Professor of Entomology
Member of the Biochemistry and Molecular Biology Group
BMB is here
- Education:
- Appointment:
- 25% Instruction and Research
- 75% Organized Research
Teaching: Insect Physiology, Seminar in Insect
Physiology Research Interests: Molecular basis of the
highly selective and sensitive insect olfactory system, in
particular, the mechanism(s) involving the fast transport (and
inactivation) of airborne odour molecules (pheromones and other
semiochemicals) through the aqueous environment of the olfactory
sensillum surrounding the olfactory receptors. Isolation,
identification, and cloning of the genes encoding odourant-binding
proteins and odourant-degrading enzymes and expression of proteins
for structural and biophysical studies of pheromone perception.
Also, I am interested in isolation, identification and synthesis
of insect pheromones and other
semiochemicals.
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Selected Publications:
1. Leal, Walter S. 1996. Chemical communication in scarab beetles:
Reciprocal behavioral agonist-antagonist activities of chiral pheromones.
Proceedings of the National Academy of Sciences of the USA 93:
12112-12115.
2. Leal, Walter S., Paulo H. G. Zarbin, Hubert
Wojtasek, Shigefumi Kuwahara, Makoto Hasegawa and Yasuo Ueda. 1997.
Medicinal alkaloid as a sex pheromone. Nature 385: 213.
3. Leal,
Walter S. 1998. Chemical ecology of phytophagous scarab beetles. Annual
Review of Entomology 43: 39-61.
4. Sandler, Benjamin H., Larisa
Nikonova, Walter S. Leal, and Jon Clardy. 2000. Sexual attraction in the
silkworm moth; structure of the pheromone-binding-protein-bombykol
complex. Chemistry and Biology 7: 143-151.
5. Leal, Walter S. 2000.
Duality monomer-dimer of the pheromone-binding protein from Bombyx mori.
Biochemical and Biophysical Research Communications 268:
521-529.
6. Horst, R., Damberger, F., Luginbuhl, P., Guntert, P., Peng, G., Nikonova, L., Leal, W.S. and Wuthrich, K. 2001. NMR structure reveals intramolecular regulation mechanism for pheromone binding and release. Proc. Natl. Acad. Sci. USA, 98, 14374-14379.
7. Nikonov, A. A. and Leal, W. S.2002. Peripheral coding of sex pheromone and behavioral antagonist in the Japanese beetle. J. Chem. Ecol. 28, 1079-1093.
8. Nikonov,A. A., Peng, G., Tsurupa,G., Leal, W. S. 2002. Unisex pheromone detectors and pheromone-binding proteins in scarab beetles. Chem. Senses, 27, 495-504.
9. Ishida, Y., Cornel, A. J., and Leal, W. S. 2002. Identification and cloning of a female antenna-specific odorant-binding protein in the mosquito Culex quinquefasciatus. J. Chem. Ecol. 28, 867-871.
10. Ishida, Y., Chiang, V. P., and Leal, W. S. 2002. Protein that makes sense in the Argentine ant. Naturwissenschaften, 89, 505-507.
11. Ishida, Y. and Leal, W. S. 2002. Cloning of putative odorant-degrading enzyme and
integumental esterase cDNAs from the wild silkmoth, Antheraea polyphemus. Insect
Biochem. Molec. Biol., 32, 1775-1780.
12. M. Maibeche-Coisne, A. A. Nikonov, Y. Ishida, E. Jacquin-Joly, and W. S. Leal, Pheromone anosmia in a scarab beetle induced by in vivo inhibition of a pheromone-degrading enzyme, Proc. Natl. Acad. Sci. USA, vol. 101, pp. 11459-11464, 2004.
13. W. S. Leal, Pheromone unwrapping by pH flip-flopping, Chem. Biol., vol. 11, pp. 1029-1031, 2004.
14. Y. Ishida, A. M. Chen, J. M. Tsuruda, A. J. Cornel, M. Debboun, and W. S. Leal, Intriguing olfactory proteins from the yellow fever mosquito, Aedes aegypti, Naturwissenschaften, vol. 91, pp. 426-431, 2004.
15. W. S. Leal, Pheromone reception. Top. Curr. Chem., vol. 240, pp. 1-36, 2005.
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